March 29, 2024

New-onset diabetes provides ‘window of opportunity’ for early pancreatic cancer detection – Healio

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Source/Disclosures

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Source:
Chari ST, et al. Gastroenterology. 2005;doi: 10.1016/j.gastro.2005.05.007.

Disclosures:
Wolpin reports research funding from Celgene and Eli Lilly & Co. and consulting for BioLineRx, Celgene and GRAIL. Chari, Feng, Goo…….

Source/Disclosures

Published by:

Source:
Chari ST, et al. Gastroenterology. 2005;doi: 10.1016/j.gastro.2005.05.007.

Disclosures:
Wolpin reports research funding from Celgene and Eli Lilly & Co. and consulting for BioLineRx, Celgene and GRAIL. Chari, Feng, Goodarzi, and Petrov report no relevant financial disclosures.

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Pancreatic cancer often is called the silent killer.

Most people with early disease show no symptoms. Consequently, 80% of cases are diagnosed in late stages when surgery is no longer possible and other treatment options are limited. Fewer than 10% of patients survive 5 years after diagnosis.

Efforts to accelerate research into the link between new-onset diabetes and pancreatic cancer are critical, according to Brian M. Wolpin, MD, MPH. β€œThe idea that there may be people out there who have some signal [to show] the cancer may be present but we aren’t identifying them in a way that [allows us] to diagnosis the cancer early is upsetting,” Wolpin said.

Source: Dana-Farber Cancer Institute.

Early detection has been heralded as the holy grail to reduce mortality of pancreatic cancer, set to become the second leading cause of cancer death in the United States by 2040.

A deeper understanding of the link between new-onset diabetes and pancreatic cancer may play a key role in that effort.

One study showed individuals with new-onset diabetes are up to eight times more likely than the general population to develop pancreatic cancer. Another suggested the increased risk for pancreatic cancer among people with new-onset diabetes is comparable to the elevated risk for lung cancer observed among those who smoked a pack of cigarettes per day for 2 decades.

A history of pancreatitis also may be a key indicator, with a study showing patients with diabetes that developed secondary to a pancreatitis attack had a seven times higher risk for pancreatic cancer than individuals with type 2 diabetes.

Two major research collaborations are underway to explore the link between pancreatic cancer and new-onset diabetes.

The NCI is leading a multidisciplinary effort to determine which individuals newly diagnosed with diabetes are at elevated risk for pancreatic cancer. A second study will examine whether imaging at the time of new-onset diabetes results in earlier pancreatic cancer detection.

This potentially practice-informing research is crucial to improve the typically poor prognosis for patients with this aggressive malignancy, according to Brian M. Wolpin, MD, MPH, director of the gastrointestinal cancer center and Hale Family Center for Pancreatic Cancer Research at Dana-Farber Cancer …….

Source: https://www.healio.com/news/hematology-oncology/20211104/newonset-diabetes-provides-window-of-opportunity-for-early-pancreatic-cancer-detection

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