January 27, 2023

Insulin in a Pill? New Research Answers a Question That Has Puzzled Diabetes Researchers for 100 Years – SciTechDaily

Insulin is a hormone that plays a critical role in the regulation of glucose (sugar) levels in the blood. It is produced by the pancreas and helps the body use glucose for energy. In individuals with diabetes, the body is either not producing enough insulin or is unable to use it effectively, leading to high blood sugar levels.

Researchers at WEHI have solved a century-old question in diabetes research by discovering that a molecu…….

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Insulin is a hormone that plays a critical role in the regulation of glucose (sugar) levels in the blood. It is produced by the pancreas and helps the body use glucose for energy. In individuals with diabetes, the body is either not producing enough insulin or is unable to use it effectively, leading to high blood sugar levels.

Researchers at WEHI have solved a century-old question in diabetes research by discovering that a molecule other than insulin can have the same effect. This provides valuable information for the future creation of an oral insulin pill.

Researchers at the Walter and Eliza Hall Institute (WEHI) in Melbourne have finally answered a question that has puzzled diabetes researchers for a century: can a molecule other than insulin have the same effect? The team’s findings provide crucial insight into the development of an oral insulin pill.

They have successfully demonstrated how a non-insulin molecule can imitate insulin, which is essential for maintaining blood sugar levels.

The WEHI-led study opens new avenues for the development of drugs that could replace daily insulin injections for people with type 1 diabetes.

L-R: Professor Mike Lawrence, Dr. Nicholas Kirk, and Mai Margetts have produced the first 3D images of an insulin-mimicking molecule interacting with the insulin receptor. Credit: WEHI

At a glance

  • Researchers have visualized precisely how an insulin-mimicking molecule reproduces the activity of insulin to regulate blood glucose levels
  • The study answers a century-old question of whether it is possible to replace insulin
  • Findings illuminate new opportunities for the development of oral insulin mimetics that may replace daily injections by type 1 diabetics
  • People with type 1 diabetes cannot produce insulin and require multiple daily insulin injections to keep their blood glucose levels in check.

The new research confirms that alternative molecules can be used to turn on blood glucose uptake, bypassing the need for insulin altogether.

The study, published in Nature Communications, was led by WEHI’s Dr. Nicholas Kirk and Professor Mike Lawrence, in collaboration with researchers from Lilly, an American-based pharmaceutical company.

A 3D image showing how an insulin mimicking molecule (…….

Source: https://news.google.com/__i/rss/rd/articles/CBMif2h0dHBzOi8vc2NpdGVjaGRhaWx5LmNvbS9pbnN1bGluLWluLWEtcGlsbC1uZXctcmVzZWFyY2gtYW5zd2Vycy1hLXF1ZXN0aW9uLXRoYXQtaGFzLXB1enpsZWQtZGlhYmV0ZXMtcmVzZWFyY2hlcnMtZm9yLTEwMC15ZWFycy_SAQA?oc=5