March 28, 2024

Association Between Vibration Detection Threshold and Sensory Response in Diabetes – Neurology Advisor

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Sufferers with type 1 diabetes (T1D) Might Even be extra hypoalgesic to bone strain ache detection thresholds (pPDT) and strain ache tolerance thresholds (pPTT), Regardless of decrease vibration detection thresholds (VDT), Based mostly on outcomes of a research recently revealed in Entranceiers in Pain Evaluation.

This cross-sectional research embraced 122 healthful patients and 155 with diabetes. Of patients with diabetes, 56 had T1D and 99 had type 2 diabetes (TD2). Sufferers with…….

Sufferers with type 1 diabetes (T1D) Might Even be extra hypoalgesic to bone strain ache detection thresholds (pPDT) and strain ache tolerance thresholds (pPTT), Regardless of decrease vibration detection thresholds (VDT), Based mostly on outcomes of a research recently revealed in Entranceiers in Pain Evaluation.

This cross-sectional research embraced 122 healthful patients and 155 with diabetes. Of patients with diabetes, 56 had T1D and 99 had type 2 diabetes (TD2). Sufferers with T1D and T2D have been assessed and in contrast in the direction of Every completely different for VDT (regular, <18 V; middleman, 18-25 V; extreme, >25 V), pPDT, pPTT, tonic chilly ache by way of hand immersion in ice water, and central ache mechanisms, collectively with conditioned ache modulation and temporal summation. Comparability between teams was carried out using a linear regression or nonparametric linear regression mannequin.

Compared with healthful patients, and with modifications for physique mass index, age, and intercourse, these with diabetes had elevated pPDT at L4 tibia (kilopascals [kPa], 98; 95% CI, 76-126 vs kPa, 72; 95% CI, 56-96, respectively; P =.01), elevated tonic chilly ache hyperalgesia (kPa, 103; 95% CI, 92-112 vs kPa, 92; 95% CI, 69-110, respectively; P <.01), and decreased temporal summation Inside the arm (kPa, 0; 95% CI, 0-0 vs kPa, 1; 95% CI, 0-2, respectively; P <.01) and stomach (kPa, 0; 95% CI, 0-0 vs kPa, 1; 95% CI, 0-2, respectively; P <.01). Sufferers with T1D have been hyperalgesic to tibial pPDT (P <.01) and pPTT (P <.01), And in addition had decreased VDTs (7 V; P =.02) in contrast with these with T2D. No affiliation was noticed between VDT and quantitative sensory testing.


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Limitations to this research embrace Using completely different websites for research, As properly as to potential selection bias.

The researchers concluded That There is a β€œco-existence of hypoesthesia to phasic bone strain and hyperalgesia to tonic chilly ache [amongst these with diabetes] As in contrast [with] healthful [patients], even after modifications.” Furtherextra, β€œthe protocol revealed variations in responses to bone ache between [patients with] T1D [vs these with] T2D,” Which Might Even be of curiosity in future research.

Reference

Hansen LEM, Fjelsted CA, Olesen SS, et al. Straightforward quantitative sensory testing reveals paradoxical co-existence of hypoesthesia and hyperalgesia in diabetes. Published on-line June 28, 2021. Entrance Pain Res. doi: 10.3389/fache.2021.701172

This textual content material initially appeared on Medical Pain Advisor

Source: https://www.neurologyadvisor.com/topics/pain/bone-pressure-pain-and-tolerance-thresholds-in-patients-with-diabetes-2/

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